Zenex Otirel (15ml) is a multi-action, prescription-strength veterinary otic solution formulated to target and resolve acute or chronic external ear infections (otitis externa) in dogs and cats. This specialized therapeutic formula relies on a synergistic combination of four active ingredients to combat infection, eliminate pain, and manage localized tissue swelling: Ofloxacin (0.3% w/v), Clotrimazole (1.0% w/v), Betamethasone Dipropionate (0.025% w/v), and Lignocaine Hydrochloride (2.0% w/v).

Each active component addresses a specific pathological element of a complex ear infection:

• Antibacterial Action: Ofloxacin is a broad-spectrum, second-generation fluoroquinolone antibiotic that eradicates susceptible Gram-positive and Gram-negative bacterial pathogens by inhibiting their DNA enzymes.
• Antifungal Power: Clotrimazole delivers dedicated antifungal action to clear away opportunistic yeast overgrowths like Malassezia pachydermatis, which thrive in moist, waxy ear canals.
• Anti-Inflammatory Relief: Betamethasone Dipropionate acts as a potent topical corticosteroid to rapidly minimize painful canal swelling, reduce redness, and stop intense internal itching.
• Instant Pain Management: Lignocaine Hydrochloride (Lidocaine) serves as a fast-acting local anesthetic, temporarily blocking pain signals along nerve pathways to prevent agonizing scratching and violent head-shaking.

Critical Safety Warning: Otirel Ear Drops must never be administered if the pet's eardrum (tympanic membrane) is torn, ruptured, or perforated. Introducing topical medications containing aminoglycosides, fluoroquinolones, or steroids into a compromised ear canal can lead to permanent hearing loss or severe vestibular toxicity (loss of balance). A veterinarian must always confirm the eardrum is completely intact using an otoscope prior to initiating treatment.